research

Current and past research

We cooperate with scientists and clinics to provide evidence of concrete therapeutic benefits.

Publications

  • Linnemann, C.; Sahin, F.; Chen, Y.; Falldorf, K.; Ronniger, M.; Histing, T.; Nussler, A.K.; Ehnert, S. NET FormationWas Reduced via Exposure to Extremely Low-Frequency Pulsed Electromagnetic Fields. Int. J. Mol. Sci. 2023, 24, 14629. https://doi.org/ 10.3390/ijms241914629.
  • Chen, Y.; Braun, B.J.; Menger, M.M.; Ronniger, M.; Falldorf, K.; Histing, T.; Nussler, A.K.; Ehnert, S. Intermittent Exposure to a 16 Hz Extremely Low Frequency Pulsed Electromagnetic Field Promotes Osteogenesis In Vitro through Activating Piezo 1-Induced Ca2+ Influx in Osteoprogenitor Cells. J. Funct. Biomater. 2023, 14, 165. https://doi.org/10.3390/jfb14030165.
  • Ronniger, M. et al; A Novel Method to Achieve Precision and Reproducibility in Exposure Parameters for Low-Frequency Pulsed Magnetic Fields in Human Cell Cultures, Bioengineering 2022, 9, 595; https://doi.org/10.3390/bioengineering9100595.
  • Chen Y. et al.; Modulation of macrophage activity by pulsed electromagnetic fields in the context of fracture healing, Bioengineering 2021, 8(11), 167; https://doi.org/10.3390/bioengineering8110167.
  • Chen Y. et al.; Exposure to 16 Hz Pulsed Electromagnetic Fields Protect the Structural Integrity of Primary Cilia and Associated TGF- Signaling in Osteoprogenitor Cells Harmed by Cigarette Smoke, Int. J. Mol. Sci. 2021, 22, 7036; https://doi.org/10.3390/ijms22137036.
  • Ehnert S. et al.; Translational Insights into Extremely Low Frequency Pulsed Electromagnetic Fields (ELF-PEMFs) for Bone Regeneration after Trauma and Orthopedic Surgery., J Clin Med. 2019 Nov 20;8(12):2028. https://doi.org/10.3390/jcm8122028.
  • Ziegler, P.N. et al.; Pulsed electromagnetic field therapy improves osseous consolidation after high tibial osteotomy in elderly patients., J. Clin. Med. 2019, 8, 2008; https://doi.org/10.3390/jcm8112008.
  • Poh PSP et al.; Osteogenic Effect and Cell Signaling Activation of Extremely Low-Frequency Pulsed Electromagnetic Fields in Adipose-Derived Mesenchymal Stromal Cells., Stem Cells Int. 2018 Jul 12;2018:5402853. https://doi.org/10.1155/2018/5402853.
  • Ehnert S. et al.; Co-Culture with Human Osteoblasts and Exposure to Extremely Low Frequency Pulsed Electromagnetic Fields Improve Osteogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells., Int J Mol Sci. 2018 Mar 27;19(4):994. https://doi.org/10.3390/ijms19040994.
  • Portelli L.A. et al.; Retrospective estimation of the electric and magnetic field exposure conditions in in vitro experimental reports reveal considerable potential for uncertainty, Bioelectromagnetics. 2018 Apr;39(3):231-243. https://doi.org/10.1002/bem.22099.
  • Ehnert S. et al.; Extremely low frequency pulsed electromagnetic fields cause antioxidative defense mechanisms in human osteoblasts via induction of •O2- and H2O2., Sci Rep. 2017 Nov 6;7(1):14544. https://doi.org/10.1038/s41598-017-14983-9.
  • Ehnert S. et al.; Primary human osteoblasts with reduced alkaline phosphatase and matrix mineralization baseline capacity are responsive to extremely low frequency pulsed electromagnetic field exposure — Clinical implication possible., Bone Rep. 2015 Aug 18;3:48-56. https://doi.org/10.1016/j.bonr.2015.08.002.
  • Seeliger C et al.; Low-frequency pulsed electromagnetic fields significantly improve time of closure and proliferation of human tendon fibroblasts., Eur J Med Res. 2014 Jul 5;19(1):37. https://doi.org/10.1186/2047-783X-19-37.
  • Visan A; Effective acceleration of wound healing processes with the help of Cell Information Therapy (CIT) – Innovation from quantum physics., January 2008 Kosmetische Medizin 29(1):23-27.
  • Visan A; Efficacy and tolerance of cell information therapy (CIT) on wound healing processes free of transplants., January 2007 Kosmetische Medizin 28(3):112-118.
Some of our previous and current research partners as well as their research topics are listed as follows.
Siegfried Weller Institute for Traumatology Research

Topic:

Influence of CIT-technology on primary osteoblasts

Institut De Biologie Paris Seine (IBPS)

Topic:

Alleviation of Inflammation by physical (EMF + light) therapy

Mittelstand 4.0 Centre of Excellence Kiel

Topic:

Development of a wireless interface for use in a medical device environment

University of Southern Denmark

Topic:

Analysis of value proposition and patient journey regarding EMF therapy

Medical applications

Topic:

Influence of CIT-technology on the regeneration of cell cultures damaged through oxidative stress

AG Immune regulation

Topics:

  • Influence of CIT-technology on the activation status and cytokine secretion of murine CD4+ and CD8+ T-lymphocytes
  • Influence of CIT-technology on the signal transduction after TCR stimulation in human T-cell lines
Department of Applied Cell Therapy

Topic:

Influence of CIT-technology on the differentiation and function of immune oppressive macrophage populations

Computer Science VII

Topic:

Ontology based analysis and visualisation of the induced morphological changes of cells through CIT

Clinic and Polyclinic for Trauma Surgery and experimental Trauma Surgery

Topic:

Influence of CIT-technology on the osteogenic differentiation of stem cells for bone regeneration

Member of: